3 edition of Nasal toxicity and dosimetry of inhaled xenobiotics found in the catalog.
Nasal toxicity and dosimetry of inhaled xenobiotics
|Other titles||Inhalation toxicology. V. 6 (Supplement).|
|Statement||cosponsors, Chemical Industry Institute of Toxicology ... [et al.] ; organizing committee, chairman, F. Miller ... [et al.].|
|Contributions||Miller, Fred J., Boorman, Gary A., Chemical Industry Institute of Toxicology.|
|LC Classifications||RA1245 .N37 1995|
|The Physical Object|
|Pagination||x, 469 p. :|
|Number of Pages||469|
|LC Control Number||94029943|
Frederick J. Miller - Nasal Toxicity and Dosimetry of Inhaled Xenobiotics: Implications for Human Health. Chemical Industry Institute of Toxicology - Published: Frederick J. Morrison, Catherine Lord, Daniel P. Keating, eds. - Applied Developmental Psychology, Volume 2 - . Webinars and Downloads Upcoming Webinars how to best employ new dosimetry evaluation methods to characterize how exogenous exposures impact endogenous levels, and what data are needed to adequately assess the impact of exogenous exposure at the portal of entry (POE) as well as in systemic tissues. An assessment of mixture toxicity using.
xenobiotics: potentially harm-ful, lipid-soluble chemicals that are foreign to the human body. Both the route of breathing, nasal versus oral, and the effectiveness of the nose to filter inhaled, fine particles may differ between children and adults. This study compared (1) the nasal contribution to breathing at rest and during mild to moderate exercise in children (age 6–10 yr) versus young adults and (2) the nasal deposition efficiency (NDE) of fine particles (1 and 2 μm MMAD, GSD Cited by:
Xenobiotic Toxicity Innovations Xenobiotics as the name signifies â strangersâ are compounds that are foreign to human body. Xenobiotic compounds include natural as well as synthetic compounds such as pesticides, drugs, additives, heavy metals, food additives etc. Xenobiotic Toxicity Journals. Xenobiotics as the name signifies â strangersâ are compounds that are foreign to human body. Xenobiotic compounds include natural as well as synthetic compounds such as pesticides, drugs, additives, heavy metals, food additives etc. The accumulation of these compounds in the body will cause depletion of cells.
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This work addresses nasal dosimetry and toxicity of Inhaled Xenobiotics.; Originally Published As A Special Issue Of The journal "Inhalation Toxicology", the contributions are derived from a Chemical Industry Institute of Toxicology CIIT symposium held in September in Durham, North Carolina.
This work addresses nasal dosimetry and toxicity of inhaled xenobiotics. The articles cover topics ranging from how mathematical and physical models can be used to study the deposition of inhaled Read more. Nasal toxicity and dosimetry of inhaled xenobiotics: implications for human health.
G A Boorman National Institute of Environmental Health Sciences, Research Triangle Park, NC Cited by: Toxicology Studies for Inhaled and Nasal Delivery. Wolff RK(1). Author information: (1)RK Wolff - Safety Consulting Inc, Fort Myers, FloridaUnited States.
This review examines issues related to the toxicological testing of pharmaceuticals delivered by the inhalation or nasal by: This book reviews the fundamental clinical science of toxic exposures of the special senses.
Although not specifically focused on human senses, it discusses both the clinical and laboratory assessment in animals following exposure. Miller FJ, Boorman GA () Nasal Toxicity and Dosimetry of Inhaled Xenobiotics. CRC, New York. Roland PS, Rutka Author: Lewis Nelson.
A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism. It can also cover substances that are present in much higher concentrations than are usual. Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of.
DeSesso JM. Comparative anatomy and physiology of rat, monkey, and human nasal passages. conference on nasal toxicity and dosimetry of inhaled xenobiotics: Implications for human health. Durham, NC, SeptemberDeSesso JM.
The role of hydroxyl free radicals in early embryonic cell death induced by hydroxyurea. The mammalian respiratory system is susceptible to injury caused by either air- or blood-borne toxicants.
respectively) due to their more erect stature. The degree of this bend in the upper airway impacts the regional dosimetry of some inhaled agents. The presence of exudate in the nasal cavity is a valuable indication of nasal toxicity. Three-dimensional, anatomically accurate computational fluid dynamics (CFD) models of the rat, monkey, and human nasal passages have been developed to predict inhaled airflow patterns and formaldehyde uptake to elucidate the roles of nasal anatomy and airflow on formaldehyde toxicity (Kepler et al., ; Kimbell et al.,a,b Cited by: To better understand and predict gender differences in response of the nasal epithelium to inhaled xenobiotics, gene expression profiles from naive male and female Sprague-Dawley rats were.
The conceptual basis for the dosimetry adjustments applied to inhaled agents and other considerations specific to this administration route are addressed in Chapter 3. The aim of the inhalation reference concentration (RfC) methodology is to establish a relationship between a particular agent in the air and a specific health effect (or effects).
This review examines issues related to the toxicological testing of pharmaceuticals delivered by the inhalation or nasal route. The purpose of the toxicology studies is to conduct studies in animals that will aid the assessment of the safety of these agents delivered to patients. Inhalation toxicology studies present some unique issues because the dosing method differs from more standard Cited by: McClellan, RO Miller, FJ Research strategy for assessing human risk from inhaled toxicants Nasal toxicity and dosimetry of inhaled xenobiotics: Implications for human health Washington, D.
Taylor & Francis 11 21 Google ScholarCited by: Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein March Inhalation Toxicology 20(3) Advances in Toxicity Testing: New Techniques for Nasal Toxicants “Improving the methods for toxicity testing is crucial because it will allow us to generate better guidelines for exposure to inhaled toxicants such as hydrogen sulfide.” —Dr.
David Dorman, The Hamner Institutes for Health Sciences. Jarabek, A.M., “Inhalation RfC Methodology: Dosimetric Adjustments and Dose-Response Estimation of Noncancer Toxicity in the Upper Respiratory Tract,” in Nasal Toxicity and Dosimetry of Inhaled Xenobiotics, ed.
by Miller, F.J., Taylor and Francis, Washington, DC, pp. –, Google Scholar. Inhalation Toxicology, ; 21(7): – ReseaRch aRticle Dosimetry of nasal uptake of water-soluble and reactive gases: A first study of interhuman variability Guilherme J.
Garcia1, Jeffry D. Schroeter1, Rebecca A. Segal2, John Stanek3, Gary L. Foureman3, and Julia S. Kimbell1 1The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, 2Virginia Commonwealth. and water vapor) inhaled simultaneously. The solubility of a gas in water is the major characteristic in determining the relative toxicity of the gas.
Inhaled toxicants that do not exert immediate toxic effects can pass through the lung, reach the capillaries, and be transported by the blood to other tissues where they can cause injury. xenobiotic: [ ze″no-bi-ot´ik ] a chemical compound foreign to a given biological system.
With respect to animals and humans, xenobiotics include drugs, drug metabolites, and environmental compounds such as pollutants that are not produced by the body. In the environment, xenobiotics include synthetic pesticides, herbicides, and industrial.
The most up-to-date treatment of inhalation toxicology available, Toxicology of the Lung, Fourth Edition examines the subject from a target-organ perspective. Completely revised and updated, the book includes contributions from an entirely new set of authors, each of them a Author: Taylor And Francis.
This chapter provides the committee’s review of the draft IRIS assessment that is relevant to formaldehyde toxicokinetics, carcinogenic modes of action, pharmacokinetic models, and biologically based dose-response (BBDR) models.
1 The committee comments on the Environmental Protection Agency (EPA) analysis of the fate of inhaled formaldehyde in the respiratory tract (portal of entry) and .This paper focuses on conventional and advanced promising methods for the evaluation of toxicity originated by xenobiotics in WWTPs and surface waters.
A concise review about toxicity tests applied to activated sludge and to receiving water bodies was by: 6.Comparative Structure, Function, and Toxicity of the Nasal Airways: Predicting Human Effects from Animal Studies.
Metabolism of Xenobiotics by the Respiratory Tract 4. Acute Lung Injury in Response to Toxicologic Exposures.