2 edition of Epstein-Barr virus and lymphocyte morphology in lymphoma found in the catalog.
Epstein-Barr virus and lymphocyte morphology in lymphoma
Maccon M. Keane
Written in English
Thesis (M.D.) - University College Dublin, National University of Ireland, 1995.
|Statement||Maccon M. Keane.|
Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular. 50th anniversary of the EBV (Epstein-Barr Virus) link to cancer - Cancer Research UK - Duration: Cancer Research UK 13, views.
Epstein-Barr virus is a gamma-group herpes virus that causes Infectious Mononucleosis a benign, self-limited lymphoproliferative disease that is characterized by fever,generalized lymphadenopathy, splenomegaly, sore throat and appearance in the blood of atypical activated T-lymphocytes. Lymphoma is a cancer of certain types of white blood cells (WBCs) called lymphocytes that localize in one or more lymph nodes. Lymphocytes circulate throughout the body in both the blood and the lymphatic lymphatic system consists of a network of lymph nodes and vessels (lymphatics) that drain fluids from the tissues and carry them as "lymph" through the body and back to the.
ubiquitous Epstein-Barr virus (EBV) infects not only B cells but also t and NK cells, and is associated with various lymphoid malignancies. the spectrum of EBV-associated lymphoid malignancies is expanding from Burkitt lymphoma to the newly defined systemic EBV+ t cell lymphoproliferative disease of childhood and hydroa vacciniforme-like lymphoma. Epstein-Barr virus (EBV) is a ubiquitous and predominantly B lymphotrophic human γ-herpesvirus. EBV infection of natural killer (NK) and T cells is likely to be a rare event and is strongly associated with a spectrum of lymphoproliferations characterized by the pathognomic presence of monoclonal EBV in the T and/or NK cells: EBV-associated hemophagocytic lymphohistiocytosis (EBV Cited by:
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Baumforth KR, Birgersdotter A, Reynolds GM, et al. Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells.
Am J Pathol. ; – [PMC free article]Cited by: 9. Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR et al () Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin’s lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T by: The Epstein-Barr virus (EBV) is the first identified human virus with a proven association with the pathogenesis of cancer.
To maintain the integrity of the viral genome and to “get out” of the control of the host immune system, in the phase of the latent infection EBV shows the expression of several genes, including genes for six nuclear antigens, three latent membrane proteins, two short Cited by: Epstein-Barr virus–positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a “provisional” entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid by: Epstein–Barr virus-associated Hodgkin’s lymphoma Survivors of Hodgkin’s lymphoma (HL) frequently have many years to experience the long-term toxicities of com-bined modality therapies.
Also, a signiﬁcant proportion of HL patients will relapse or have refractory disease, and less than half of these patients will respond to current File Size: KB. Category: Infectious Disease > Viruses > Epstein-Barr Virus Published Date: 05/08/ A 7-year-old boy with flu-like symptoms treated with amoxicillin presented with cervical lymphadenopathy; maculopapular rash on arms, face, and trunk; and markedly high white blood cell (WBC) count ( × 10 9/L) and high absolute lymphocyte count (85 × The Epstein-Barr virus (EBV) is the first identif ied human virus with a proven association with the pathogenesis of can cer.
T o m aintain the inte grity of the viral genom e and to “get out” of. proteins in Epstein-Barr virus (EBV)-positive HL may also contribute to increased PD-1 ligand expression. The functional importance of PD-1 T cell-dependent immunoevasion by the HRS cells of cHL is illustrated downregulation in HL cell lines induces cell death ; the roles of JAK2 amplification in enhanced JAK-STAT signaling and PDL1 and PDL2 in immune evasion are discussed below.
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is defined as patients older than 50 years alone. However, Cited by: Epstein-Barr virus positive peripheral T cell lymphoma (EBV + PTCL) is a rare type of lymphoproliferative disorder which is always present in late adulthood.
However, pediatric EBV + PTCL is extremely rare and always present with lymphadenopathy. Additionally, gene detection was not performed in all of these pediatric patients. We report an EBV + PTCL in a 9-year-old child with initial Author: Zihang Chen, Limin Gao, Mi Wang, Yuan Tang, Sha Zhao, Weiping Liu.
Hodgkin lymphoma (HL) is a curable malignancy which shows a bimodal curve in incidence in economically developed countries; there is a putative association with Epstein–Barr virus.
The WHO classiﬁcation schema recognises two histological types of HL: the nodular. Hodgkin’s Lymphoma has long been suspected to have an infectious precursor, and indirect evidence has implicated Epstein-Barr virus (EBV), as a causal agent.
The etiology of EBV-negative cases Author: Richard F Ambinder. Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g.
Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma. Epstein-Barr virus–positive nodular lymphocyte predominant Hodgkin lymphoma Author links open overlay panel Shi Wang MD a b L.
Jeffrey Medeiros MD a Zijun Y. Xu-Monette PhD a Shanxiang Zhang MD, PhD c Dennis P. O’Malley MD, PhD d Attilio Orazi MD, PhD e Zhuang Zuo MD, PhD a Carlos E. Bueso-Ramos MD, PhD a Cameron C.
Yin MD, PhD a Zhiyu Liu Cited by: 6. Virus du lymphome de Burkitt, Virus Epstein-Barr, Human herpesvirus 4, Virus de la mononucléose infectieuse, EBV (Epstein-Barr Virus), HHV-4 (Human HerpesVirus 4), Burkitt's lymphoma virus, Infectious mononucleosis virus, Herpèsvirus humain de type 4: Swedish: Herpesvirus 4, humant: Czech.
Epstein-Barr virus-positive B-cell lymphoma of the elderly at a United States tertiary medical center: an uncommon aggressive lymphoma with a Cited by: 8. Most people may associate Epstein-Barr virus with infectious mononucleosis, but the tumor virus also has been implicated in at least five kinds.
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Background: Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma such as types of aggressive non-Hodgkin lymphoma (NHL). We aimed to evaluate the prevalence of EBV in NHL and its association with clinical parameters.
Patients and Methods: twenty cases entered to our study. After re-blocking of previous paraffin embedded specimens, new slides. EPSTEIN-BARR VIRUS: HISTORY• InSprunt and Evans • published cases of spontaneously resolving acute leukemia associated with blast-like cells in the blood• InDowney and McKinlay • detailed description of the lymphocyte morphology.•.
Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein–Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ().The hallmark of all BL tumours is the translocation between the MYC gene and one of the immunoglobulin (Ig) heavy or light chain loci.
There is a low background incidence of BL Cited by: Abstract. Epstein—Barr virus has been associated with a variety of malignancies.
Originally discovered in African Burkitt’s lymphoma, it is also found in lymphoproliferative disease arising in immunocompromised populations, in Hodgkin’s disease, and in peripheral T-cell by: Infectious mononucleosis is caused by the virus known as Epstein Barr virus(EBV).
This belongs to the Herpes family. It is nm, double-stranded DNA, icosahedral, enveloped. It infects the B-lymphocytes. These B-lymphocytes after the infection looks like T-lymphocytes.
The habitat for the virus is B-lymphocytes and epithelial cells of the.